Histopathological evaluation of experimentally induced volumetric muscle loss in rats
DOI:
https://doi.org/10.52331/v31i3dw89Keywords:
volumetric muscle loss, immunohistochemestry; ratsAbstract
Unlike minor muscle injuries, which can heal through the activation of resident satellite cells, VML injuries involve the removal of large tissue volumes and disruption of the extracellular matrix architecture required for effective regeneration. Consequently, the healing process is often dominated by fibrosis, chronic inflammation, and incomplete muscle regeneration. To overcome these limitations, considerable attention has been directed toward the development of biomimetic scaffolds and regenerative therapies designed to restore both the structural organization and functional properties of skeletal muscle. Understanding the histopathological changes associated with VML is therefore crucial for assessing tissue repair and for developing effective treatment strategies capable of improving muscle recovery and functional outcomes.
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